CD146 Antibody – Regulating Lipid Metabolism and Energy Homeostasis for Obesity Intervention
CD146 Antibody – Regulating Lipid Metabolism and Energy Homeostasis for Obesity Intervention
Concept
CD146 (also known as MCAM, melanoma cell adhesion molecule) is a cell-surface transmembrane glycoprotein minimally expressed in healthy adult tissues but significantly upregulated in adipose tissue during obesity. It acts as a key regulator of adipocyte differentiation, lipid synthesis, fatty acid oxidation, and brown adipose tissue thermogenesis, making it a novel target for metabolic syndrome and obesity intervention.
Research Frontier
Emerging evidence identifies CD146 as a critical metabolic regulator in white and brown adipose tissue. Current research focuses on CD146‑mediated signaling pathways, ligand interactions (ANGPTL2, galectin‑1), and CD146‑blocking antibodies as potential therapeutic agents to suppress adipogenesis, restore energy expenditure, and reverse obesity‑related metabolic dysfunction.
Research Significance
CD146 is a pivotal molecular driver of obesity:
- Promotes white adipocyte differentiation and lipid accumulation
- Inhibits fatty acid oxidation and energy dissipation
- Suppresses brown adipose tissue thermogenesis via UCP1 downregulation
- Contributes to insulin resistance and chronic low‑grade inflammation
- Serves as a novel target for antibody‑based anti‑obesity therapy
Core Mechanisms and Research Methodology
CD146 Expression in Adipose Tissue
- Strongly elevated in obese human and animal adipose tissue
- Positively correlated with obesity severity across multiple models
- Specifically enriched in fat tissue, providing a safe therapeutic target
Regulatory Roles in Adipogenesis
- Acts as a receptor for ANGPTL2
- Activates CREB signaling to drive white adipocyte differentiation
- Adipocyte‑specific CD146 knockout reduces fat mass and improves metabolism
Metabolic Functions in Mature Adipocytes
- Enhances lipogenic gene expression and lipid storage
- Reduces fatty acid oxidation
- Promotes pro‑inflammatory adipokine secretion
- Contributes to obesity‑associated chronic inflammation
Energy Homeostasis Regulation
- In brown adipose tissue, CD146 binds galectin‑1
- Represses UCP1 expression and impairs thermogenesis
- Reduces energy expenditure and promotes obesity
CD146 Antibody Therapy Potential
- Blocking CD146 with specific antibodies inhibits ligand binding
- Reduces white adipose tissue expansion and lipid accumulation
- Restores brown fat thermogenesis and energy consumption
- Improves insulin sensitivity, fatty liver, and systemic inflammation
Product Empowerment
ANT BIO PTE. LTD. provides the Rat Anti-Mouse CD146 Monoclonal Antibody (S-R606, Cat. No. S0B1299) under its Starter product line. This high‑specificity, high‑affinity reagent enables accurate detection and functional study of mouse CD146 in metabolic research, tumor biology, and immunology.
It supports mechanistic studies of CD146 in obesity, angiogenesis, immune cell profiling, and therapeutic antibody development.
Core Product Advantages
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Core Product Advantages |
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High Specificity & Target Recognition: Specifically binds mouse CD146; validated by flow cytometry and IHC; reliable for endothelial, immune, and tumor cell identification. |
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Superior Stability & Batch Consistency: Rigorous QC ensures minimal intra‑ and inter‑batch variation; highly reproducible results for metabolic and tumor research. |
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Broad Functional Compatibility: Supports detection, localization, and functional intervention studies in multiple in vitro and in vivo models. |
Key Application Scenarios
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Key Application Scenarios |
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Metabolic & Obesity Research: Study CD146 expression and function in adipose tissue and metabolic regulation. |
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Angiogenesis Assays: Detect CD146 in vascular endothelial cells during tumor and retinal vascularization. |
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Tumor Metastasis Research: Explore roles in EMT, migration, and metastasis of melanoma and other cancers. |
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Immune Cell Analysis: Identify and characterize CD146‑positive T‑cell subsets. |
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Stem & Progenitor Cell Research: Label and track mesenchymal and endothelial progenitor cells. |
Brand Mission
ANT BIO PTE. LTD. is a leading provider of life science reagents, offering antibodies, recombinant proteins, assay kits, and general laboratory reagents. We operate three specialized sub‑brands: Absin (general reagents & kits), Starter (antibodies), and UA (recombinant proteins), delivering integrated solutions for metabolism research, oncology, immunology, and translational medicine. We are committed to supplying high‑quality, consistent, and innovative tools to accelerate breakthroughs in metabolic disease therapy and precision medicine.
Related Product List
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Product Name |
Catalog No. |
Applications |
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Rat Anti-Mouse CD146 Monoclonal Antibody (S-R606) |
S0B1299 |
Flow cytometry, IHC, IF, functional studies |
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CD146 Signaling Pathway Antibody Panel |
Starter series |
Lipid metabolism and adipogenesis research |
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Protein Extraction & Lysis Buffers |
Absin series |
Sample preparation for metabolic assays |
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Recombinant Mouse CD146 Protein |
UA-series |
Antigen validation and binding assays |
Brand Promotion Copy
ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.
