CD146 antibody: How to intervene in obesity by regulating lipid metabolism and energy homeostasis?

1. What are the expression characteristics and biological significance of CD146 in adipose tissue?

CD146, as a cell surface adhesion molecule, exhibits low expression levels in normal adult tissues but shows significantly high expression in adipose tissue. This specific expression pattern suggests its potential unique function in adipose biology. Studies indicate that in obese individuals, CD146 expression in adipose tissue is further upregulated, and this change positively correlates with the degree of obesity. Validation through various obese animal models, including high-fat diet-induced, age-related, and genetically obese models, consistently demonstrates high CD146 expression in adipose tissue, indicating a close association between this molecule and the development of obesity.

2. What regulatory role does CD146 play in adipocyte differentiation?

During the differentiation of adipocyte precursors into mature adipocytes, CD146, as a functional receptor for angiopoietin-like protein 2, promotes the differentiation of white adipocytes by activating the cAMP response element-binding protein signaling pathway. This discovery reveals the critical role of CD146 in the early stages of adipogenesis. Gene knockout experiments confirm that specifically knocking out CD146 in adipocytes significantly inhibits excessive accumulation of white adipose tissue while improving insulin sensitivity and alleviating chronic inflammatory states, providing new insights into the molecular mechanisms of obesity.

3. How does CD146 affect the metabolic functions of mature adipocytes?

In mature white adipocytes, CD146, through interaction with its ligands, participates in regulating various metabolic-related processes. On one hand, CD146 signaling promotes the expression of genes related to lipid synthesis, enhancing the lipid storage capacity of adipocytes. On the other hand, this signaling pathway inhibits fatty acid oxidation, reducing lipid catabolism. Additionally, CD146 regulates the secretion of inflammatory factors, contributing to the establishment of the chronic inflammatory microenvironment associated with obesity. These multiple effects collectively promote lipid metabolic imbalance and adipose tissue expansion.

4. What special role does CD146 play in energy homeostasis regulation?

In brown adipose tissue, CD146 exhibits unique regulatory functions. Research shows that CD146, by binding to galectin-1, suppresses the expression of uncoupling protein 1, thereby reducing the thermogenic activity and energy expenditure efficiency of brown adipose tissue. This mechanism provides a new molecular basis for explaining reduced energy expenditure in obese states. Notably, CD146 mediates differential functions in white and brown adipose tissue through different ligands, reflecting its complexity in energy metabolism regulation.

5. What potential value does CD146-targeted antibody therapy have?

Specific monoclonal antibodies targeting CD146 can effectively block its interaction with ligands, demonstrating significant anti-obesity effects in animal models. Antibody therapy not only inhibits abnormal hyperplasia and lipid accumulation in white adipose tissue but also promotes the thermogenic function of brown adipose tissue, achieving bidirectional regulation. This therapeutic strategy also shows good efficacy in improving obesity-related metabolic complications, including alleviating fatty liver lesions, enhancing insulin sensitivity, and mitigating chronic inflammatory states. These findings provide a promising target for developing new anti-obesity drugs.

6. What are the clinical translation prospects of CD146 research?

Given the central role of CD146 in lipid metabolism and energy balance, intervention strategies targeting this molecule hold significant clinical translation potential. First, the specific high expression of CD146 in adipose tissue provides a good safety foundation for targeted therapy. Second, this molecule participates in obesity development through multiple mechanisms, potentially achieving more comprehensive therapeutic effects. Additionally, the advantages of CD146 antibody therapy in improving various obesity complications make it a potential new strategy for the comprehensive management of metabolic syndrome. Future research needs to further clarify the expression characteristics and regulatory mechanisms of CD146 in different populations to provide a basis for precision medicine.

7. Conclusion

As a newly discovered obesity-related molecule, CD146 plays an important role in the development of obesity by regulating adipocyte differentiation, lipid metabolism, and energy expenditure. Its differential regulation of white and brown adipose tissue functions reflects the precision and complexity of energy metabolism regulation. CD146-targeted antibody therapy demonstrates good anti-obesity effects in preclinical studies, providing new ideas and targets for the prevention and treatment of obesity and its complications. With further elucidation of CD146's functional mechanisms, this target is expected to demonstrate significant value in the treatment of metabolic diseases.

8. Which manufacturers provide CD146 antibodies?

Hangzhou Start Biotech Co., Ltd. has independently developed the "Rat Anti-Mouse CD146 Antibody" (product name: Rat Anti-Mouse CD146 Antibody (S-R606), catalog number: S0B1299), a high-specificity, high-affinity, and highly stable cell adhesion molecule detection tool. This product can accurately identify mouse melanoma cell adhesion molecule (CD146/MCAM) and has important application value in mouse models of angiogenesis, tumor metastasis mechanisms, and immune cell migration.

Professional Technical Support: We provide detailed product technical materials, including complete specificity validation data, application protocols, and professional technical support, fully assisting customers in making progress in vascular biology and tumor metastasis research.

Hangzhou Start Biotech Co., Ltd. is committed to providing high-quality, high-value biological reagents and solutions to global innovative pharmaceutical companies and research institutions. For more details about the "Rat Anti-Mouse CD146 Antibody" (catalog number S0B1299) or to request sample testing, please feel free to contact us.

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