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Cathepsin F His Tag Protein, Human

Cathepsin F His Tag Protein, Human

Catalog Number: UA011221 Brand: UA BIOSCIENCE
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$250 USD
$250 USD
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Product Details

Product Specification


Species Human
Synonyms Cathepsin F,CTSF
Accession Q9UBX1
Amino Acid Sequence

Ala20-Asp484 with His Tag at the C-Terminus
Expression System HEK293
Molecular Weight

60-75kDa (Reducing)
Purity ＞95% by SDS-PAGE
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Wang X, Zhu Z. Unraveling the causal relationship and underlying mechanisms between cathepsins on liver cancer: findings from mendelian randomization and bioinformatics analysis. Discov Oncol. 2025 Mar 7;16(1):277.
2.Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW. Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration. Mol Neurodegener.

Background

CTSF (Cathepsin F) is a cysteine protease primarily localized in lysosomes. Its protein structure contains a typical catalytic domain of cysteine proteases, which specifically cleaves peptide bonds through its active site. Within the cell, it is responsible for degrading abnormal or damaged proteins and participates in antigen processing and presentation, thereby regulating immune responses. Clinically, aberrant expression or dysfunction of CTSF is closely associated with various diseases: its overexpression may promote tumor invasion and metastasis, while in autoimmune diseases, it may lead to immune imbalance due to disrupted antigen processing. Consequently, CTSF has emerged as a potential disease biomarker and therapeutic target.

Picture

SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).