Invivo Anti-Human CD54 (ICAM-1) Recombinant mAb
Invivo Anti-Human CD54 (ICAM-1) Recombinant mAb
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | ICAM-1/CD54 |
| Synonyms | Intercellular adhesion molecule 1; Major group rhinovirus receptor; ICAM1 |
| Location | Membrane |
| Accession | P05362 |
| Clone Number | S-3807 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | in vitro T cell stimulation/activation |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
ICAM-1/CD54 is an 85–110 kDa transmembrane glycoprotein of the immunoglobulin superfamily that is expressed on endothelial, epithelial and immune cells; upon binding its ligands LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) it serves as the critical adhesion checkpoint that promotes firm leukocyte arrest on the vessel wall, enables subsequent diapedesis into inflamed tissue, and amplifies antigen-specific T-cell activation, thereby positioning it at the mechanistic center of inflammatory, autoimmune and anti-tumor immune responses.
