Mouse IL-10 Serum & Plasma & Cell culture extracts OneStep ELISA Kit

Mouse Interleukin-10 (IL-10) is a potent, pleiotropic cytokine that plays a critical role as a central regulator of immune responses; it is a homodimeric protein produced by a wide variety of immune cells, including macrophages, dendritic cells, and T and B lymphocytes, and its primary biological function is to limit and ultimately terminate inflammatory responses by inhibiting the expression of pro-inflammatory cytokines (such as TNF-α, IL-1, and IL-6) and chemokines from activated macrophages and dendritic cells, while also downregulating major histocompatibility complex (MHC) class II and co-stimulatory molecules to suppress antigen presentation and T-cell activation. By controlling the magnitude and duration of inflammation, Mouse IL-10 is essential for protecting the host from immunopathology during infections and autoimmune reactions, though its potent anti-inflammatory activity can also be exploited by pathogens to evade the immune system; due to its central role in immune homeostasis, the IL-10 gene knockout mouse is a valuable model for studying inflammatory bowel disease (IBD) and other chronic inflammatory conditions.