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TfR/CD71 His Tag Protein, Cynomolgus

TfR/CD71 His Tag Protein, Cynomolgus

Catalog Number: UA010408 Brand: UA BIOSCIENCE
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$480 USD
$480 USD
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Product Details

Product Specification


Species Cynomolgus
Synonyms CD71,TFRC,TFR,sTfR,TfR1,Trfr,T9,p90
Accession A0A2K5X958
Amino Acid Sequence

Cys89-Phe760, with N-terminal 10*His
Expression System HEK293
Molecular Weight

83-90kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1、Kawabata H. (2019) Transferrin and transferrin receptors update. Free Radic Biol Med. 133:46-54.

2、Daniels T R. et al. (2006) The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 121: 144-158.

Background

The major protein essential for the uptake of iron is transferrin receptor (TfR), encoded by TFRC, which is found primarily as a homodimer. TfR is a type II transmembrane glycoprotein that is endocytosed from the cell membrane after binding iron with transferrin (Tf), a serum iron carrier protein. TfR was found to affect many aspects of tumorigenesis, such as cancer cell proliferation, migration, invasion, metastasis and apoptosis. TfR expression was consistent with the asthma severity index, especially the proinflammatory M1 macrophage phenotype. TfR expression may be a good marker to indicate asthma severity. Increased TfR expression and decreased methylation levels of TfR were strongly correlated with multiple clinicopathological parameters. Elevated TfR expression was associated with a poor survival rate in BC patients. TfR is a new independent prognostic biomarker and a potential target for immunotherapy in BC.

Picture

SDS-PAGE

1μg (R: reducing conditions, N: non-reducing conditions).

ELISA

Immobilized TfR/CD71 His Tag Protein, Cynomolgus (Cat. No. UA010408) at 2 µg/mL (100 µL/well) can bind Biotinylated Transferrin His&Avi Tag Protein, Human with a linear range of 5.4–8.5 ng/mL