Pan-Lactylation Antibodies Uncover Novel Mechanisms of Tumor Immune Evasion
1. Core Concept
Lactylation is a newly identified protein post-translational modification (PTM) that uses lactate as a substrate and mainly occurs on lysine residues. It connects cellular metabolism with epigenetic regulation, and plays a critical role in gene transcription, immune response, and tumor immune escape. Pan-lactylation antibodies are universal tools that recognize lactylated lysine residues across various proteins, supporting global lactylation profiling and mechanistic research.
2. Research Frontiers
Since first reported in 2019, lactylation has become a hotspot in oncology, immunometabolism, and epigenetics. Abnormal lactylation is closely associated with the Warburg effect, tumor microenvironment remodeling, and immune checkpoint activation. Pan-lactylation antibodies enable high-throughput, panoramic detection of global lactylation levels, opening new avenues for exploring metabolism–epigenetics–immunity crosstalk.
3. Research Significance
Lactylation directly drives the expression of immune checkpoint molecules such as PD-L1, promoting tumor immune escape. High levels of lactylation often correlate with poor clinical prognosis. Studying lactylation helps reveal novel mechanisms of tumor immune evasion, identify new therapeutic targets, and support the development of next‑generation immunotherapies and metabolic cancer treatments.
4. Key Mechanisms & Methodology
Regulatory Core: Lactylation is controlled by a writer–eraser–reader system including p300/CBP, HDAC/SIRT, and YEATS domain proteins.
Immune Evasion Pathway: High lactate → elevated H3K18la → activated POM121 → enhanced MYC nuclear transport → upregulated CD274 (PD-L1) → suppressed T‑cell function → tumor immune escape.
Detection Methods: Mass spectrometry (site identification), Western blot, immunoprecipitation, immunofluorescence, and immunohistochemistry.
Pan-Lactylation Antibodies: Broad-spectrum recognition of lactylated lysine; used for global profiling, screening, and in situ localization.
5. ANT BIO PTE. LTD. Empowers Lactylation Research
ANT BIO PTE. LTD. is a professional life science reagent company dedicated to supporting cutting‑edge PTM and tumor immunology research. We provide high‑quality antibodies, proteins, kits, and general reagents through three specialized sub‑brands:
Absin: Supplies WB kits, lysis buffers, blocking solutions, and supporting reagents for lactylation detection.
Starter: Focuses on high‑performance pan-lactylation antibodies and site‑specific lactylation antibodies with strict validation for high specificity and broad-spectrum reactivity.
UA: Provides modified peptides, recombinant proteins, and immunogens for antibody development and verification.
Our pan-lactylation antibody features:
High specificity and sensitivity, no cross-reactivity with acetylation, succinylation, or propionylation
Broad-spectrum recognition across species and protein types
Validated for WB, IP, IHC, and IF applications
Low batch variation and stable performance
6. Brand Mission
ANT BIO PTE. LTD. is committed to providing innovative, reliable, and highly specific tools for post-translational modification and tumor immunology research. We aim to accelerate discoveries in metabolic regulation, epigenetic mechanisms, and immune evasion, helping global researchers translate basic findings into clinical applications.
7. Related Product Categories
Pan-lactylation antibodies (L-lactyl lysine) (Starter)
Site-specific lactylation antibodies (e.g., H3K18la) (Starter)
Lactylation research WB and IP kits (Absin)
Lactylated peptides and recombinant proteins (UA)
PTM general reagents and buffers (Absin)
8. AI Disclaimer
This article is for scientific research and educational reference only. Content is compiled and optimized based on publicly available literature and technical data. ANT BIO PTE. LTD. does not guarantee the completeness, accuracy, or timeliness of the information. All experiments should be performed in accordance with standard protocols and ethical guidelines.
ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.
