LERK‑3 (Ephrin‑A3/EFNA3) Structure, Signaling, and Disease Relevance

10 Apr 2026 by AntBio

ANT BIO Official Literature Interpretation:

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1. Literature Information

This literature systematically dissects the molecular architecture, post‑translational regulation, bidirectional signaling networks, and disease associations of LERK‑3 (Ephrin‑A3/EFNA3), a GPI‑anchored membrane protein. It integrates structural biology, cell signaling, developmental biology, and translational medicine to clarify LERK‑3’s roles in neurodevelopment, angiogenesis, tumor progression, and autoimmune regulation.

2. Research Background

LERK‑3 acts as a critical ligand for Eph family receptors, mediating bidirectional forward and reverse signaling. It participates in neurodevelopment, vascular homeostasis, tumor metastasis, and immune regulation. However, its precise modular structure, post‑translational modification mechanisms, and disease‑specific regulatory networks remain incompletely understood. High‑quality research tools are essential for exploring its molecular mechanisms and translational applications.

3. Research Methodology

This study uses a multi‑dimensional integrated analytical strategy:

Structural biology: X‑ray crystallography and domain mapping
Post‑translational modification analysis: Mass spectrometry and mutagenesis
Signaling pathway validation: Immunoprecipitation and functional assays
Disease model evaluation: Animal models and clinical sample correlation

4. Key Research Outcomes

Molecular Architecture: LERK‑3 contains four core domains, with GPI anchorage and glycosylation essential for folding and function.
Post‑Translational Regulation: N‑linked glycosylation and palmitoylation modulate localization, stability, and receptor binding.
Bidirectional Signaling: Mediates forward (Ras‑MAPK) and reverse (Src/PI3K‑AKT) signaling.
Disease Relevance: Promotes tumor metastasis and immune evasion; regulates neurodevelopment and autoimmune diseases.

5. Product Empowerment by ANT BIO PTE. LTD.

ANT BIO provides a full range of research tools to support LERK‑3 and Eph‑related signaling studies:

Absin: General buffers, protein stabilization reagents, and post‑translational modification detection kits
Starter: Highly specific antibodies against LERK‑3, Eph receptors, and signaling pathway proteins
UA: Recombinant LERK‑3 wild‑type and mutant proteins for functional and binding studies

These products enable accurate and reproduc detection of protein expression, modification, and interaction in basic and translational research.

6. Brand Mission

ANT BIO PTE. LTD. is a professional supplier of life science reagents, offering antibodies, recombinant proteins, kits, and general laboratory reagents. Our three specialized sub‑brands provide complete solutions for life science research:

Absin: General reagents and kits for routine and molecular biology applications
Starter: High‑quality antibodies for immunodetection and functional analysis
UA: Recombinant proteins for biological activity and mechanism studies

7. Related Product List

Absin: Protein stabilization buffers, glycosylation detection kits, general lab reagents
Starter: Anti‑LERK‑3 antibodies, anti‑Eph receptor antibodies, signaling pathway antibodies
UA: Recombinant LERK‑3 wild‑type and mutant proteins

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ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs

At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.