Knowledge Insight: How Human IL‑28B Protein Modulates Antiviral Immunity and Inflammation
Knowledge Insight: How Human IL‑28B Protein Modulates Antiviral Immunity and Inflammation
1. Core Concepts
Interleukin‑28B (IL‑28B), also known as interferon‑λ3 (IFN‑λ3), is a pivotal member of the type III interferon (IFN‑λ) family. It combines structural features of interferons and interleukins, forming a compact helical bundle structure of approximately 20–25 kDa.
IL‑28B acts through a specific heterodimeric receptor complex composed of IL‑28Rα and IL‑10Rβ, which displays restricted tissue expression — primarily on epithelial cells and selected immune populations. This specificity supports targeted antiviral and anti‑inflammatory effects with reduced systemic toxicity.
2. Research Frontiers
IL‑28B has become a high‑interest target in antiviral immunity, inflammatory diseases, and cancer immunology. Recent advances focus on:
- Differential regulation of antiviral responses compared to type I interferons
- Dual immunomodulatory roles in pro‑ and anti‑inflammatory networks
- Genetic polymorphisms affecting therapeutic responses in viral hepatitis
- Development of IL‑28B‑based agonists and diagnostic biomarkers
- Combination strategies for cancer immunotherapy
3. Research Significance
IL‑28B is indispensable for understanding and treating infectious and immune disorders:
- Provides targeted, tissue‑specific antiviral defense
- Balances inflammatory responses to prevent immune damage
- Serves as a predictive biomarker for hepatitis C treatment outcomes
- Offers a safer alternative to type I interferons for clinical translation
- Supports drug discovery for viral diseases and immune‑mediated conditions
High‑quality recombinant IL‑28B is essential for mechanistic research and therapeutic development.
4. Biological Functions and Molecular Mechanisms
Core Physiological Functions
- Antiviral Immunity
- Directly inhibits viral replication by inducing antiviral effector proteins
- Enhances NK cell cytotoxicity and promotes Th1‑biased immune responses
- Boosts adaptive immunity against viral pathogens
- Immunomodulation and Inflammation Control
- Maintains immune balance by regulating Th1/Th2 differentiation
- Reduces excessive pro‑inflammatory cytokine release
- Supports tissue homeostasis and prevents inflammatory injury
Signaling Pathway
IL‑28B binding triggers the JAK‑STAT cascade:
- Receptor dimerization activates JAK kinases
- STAT proteins are phosphorylated and form dimers
- Activated STAT complexes translocate into the nucleus
- Transcription of interferon‑stimulated genes (ISGs) is initiated
This pathway drives the majority of IL‑28B’s biological effects.
5. Product Empowerment by ANT BIO PTE. LTD.
ANT BIO PTE. LTD. offers Human IL‑28B Protein, His Tag (Cat. No. S0A4057) under the UA sub‑brand. This mammalian‑expressed recombinant protein supports high‑level research in virology, immunology, and drug development.
Core Product Advantages
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Core Product Advantages |
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High Bioactivity & Native Conformation: Mammalian expression ensures proper folding, glycosylation, and authentic biological activity validated by ISRE reporter assays. |
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High Purity & Low Endotoxin: Purity >95% (SDS‑PAGE/HPLC); endotoxin <1.0 EU/μg, ideal for sensitive in vitro and in vivo studies. |
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Excellent Stability & Batch Consistency: Strict QC ensures reliable performance and minimal inter‑batch variation. |
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Flexible His‑Tag: Facilitates protein purification, detection, immobilization, and conjugation. |
Suitable Key Application Scenarios
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Suitable Key Application Scenarios |
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Antiviral Immunity: Study roles in HCV, HBV, influenza, and other viral infections. |
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Tumor Immunology: Explore regulation of the tumor microenvironment and immune cell functions. |
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Inflammatory & Autoimmune Diseases: Investigate immunomodulatory effects in lupus, multiple sclerosis, etc. |
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Drug Screening & Biomarkers: Screen receptor agonists/antagonists and develop diagnostic tools. |
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Signaling Pathway Research: Analyze IL‑28R binding and JAK‑STAT activation mechanisms. |
6. Brand Mission
ANT BIO PTE. LTD. is a trusted provider of life science reagents, supporting researchers worldwide with high‑performance antibodies, recombinant proteins, ELISA kits, and general laboratory reagents. We operate three specialized sub‑brands:
- Absin: General reagents, buffers, and assay kits
- Starter: High‑quality antibodies for research and diagnostics
- UA: Recombinant proteins for immunization, validation, and standardization
7. Related Product List
- Human IL‑28B Protein, His tag (UA, S0A4057)
- IL‑28B ELISA kits (Absin)
- Anti‑IL‑28B and anti‑IL‑28R antibodies (Starter)
- Immunoassay buffers and supporting reagents (Absin)
- Recombinant type III interferon family proteins (UA)
Brand Promotion Copy
ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights
