Key Roles of Prolactin Antibodies in Endocrine Disease Diagnosis ANTBIO Knowledge & Product Application
Key Roles of Prolactin Antibodies in Endocrine Disease Diagnosis
ANTBIO Knowledge & Product Application
1. Concept & Physiological Background
Prolactin (PRL) is a 198‑amino‑acid polypeptide hormone mainly produced and secreted by lactotroph cells in the anterior pituitary gland. Its secretion is tightly regulated by inhibitory and releasing factors, showing a clear circadian rhythm and reproductive cycle‑dependent fluctuation. PRL regulates mammary gland development, milk production, reproductive axis function, metabolism, bone growth, and calcium‑phosphorus balance.
2. Research Frontiers & Technical Advantages of PRL Antibodies
In modern endocrine detection, high‑quality PRL antibodies provide outstanding technical benefits:
- High specificity: Effectively avoid cross‑reactivity with growth hormone (GH), human placental lactogen (hPL), and other pituitary hormones.
- High sensitivity: Support chemiluminescence, time‑resolved fluorescence, and other signal‑amplified detection systems for trace PRL quantification.
- Molecular isoform differentiation: Distinguish monomeric PRL (23 kDa), big PRL (50–60 kDa), and macroprolactin (>100 kDa).
- Stable dynamic monitoring: Compatible with automated platforms for long‑term, reliable rhythm analysis.
- Standardized quality control: Aligned with international reference materials to ensure lab‑to‑lab comparability.
3. Research & Clinical Significance
Hyperprolactinemia (serum PRL > 25 μg/L or 1.14 nmol/L) is closely associated with menstrual disorders, infertility, galactorrhea, pituitary adenomas, hypothyroidism, medication effects, and physiological stress. PRL antibody‑based immunoassays have become essential tools for:
- Screening and differential diagnosis of menstrual irregularities and infertility
- Evaluating non‑puerperal galactorrhea
- Diagnosing and monitoring pituitary prolactinomas
- Assisting primary hypothyroidism assessment
- Investigating endocrine and reproductive pathophysiology
4. Mechanism, Detection Methods & ANTBIO Product Applications
Prolactin antibodies are core reagents for IHC, IF, WB, ELISA, and chemiluminescent immunoassays. They enable specific targeting, accurate quantification, and histological localization of PRL in tissues and biofluids.
ANT BIO PTE. LTD. has developed a high‑performance recombinant rabbit monoclonal antibody:
Prolactin/PRL Recombinant Rabbit mAb (SDT‑235‑13), Cat. No. S0B0061
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Core Product Advantages |
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High specificity and precise target recognition: Specifically recognizes human PRL with minimal cross‑reactivity to GH and hPL; accurately labels lactotroph cells in the pituitary for reliable detection and pathological diagnosis. |
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Excellent affinity and multi‑platform compatibility: Delivers clear cytoplasmic staining in IHC, specific ~23 kDa band detection in WB, and supports high‑sensitivity quantitative immunoassay development. |
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Strict QC and batch‑to‑batch consistency: Recombinant expression ensures stable performance; validated for reproducible results in long‑term research and diagnostic development. |
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Key Research and Application Values |
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Pituitary adenoma pathological diagnosis and classification: IHC gold standard for identifying prolactinomas to guide treatment and prognosis. |
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Reproductive endocrinology and physiology research: Supports studies of lactation, reproductive cycles, gonadal function, and related disease models. |
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Hyperprolactinemia etiology exploration: Investigates PRL cell abnormalities caused by drugs, hypothalamic disorders, and endocrine diseases. |
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Pituitary function evaluation: Identifies anterior pituitary hormone cells and assesses developmental or pathological changes. |
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Biomarker assay development: Serves as core raw material for serum, CSF, and supernatant quantitative detection systems. |
5. Brand Mission
ANT BIO PTE. LTD. is a leading supplier of premium life science reagents, focusing on high‑quality antibodies, recombinant proteins, assay kits, and general laboratory reagents. We operate three specialized sub‑brands:
- Absin: General reagents, buffers, and ELISA kits
- Starter: High‑performance antibodies and functional magnetic beads
- UA: Recombinant proteins for research, immunization, and validation
6. Related Product List
- Prolactin/PRL Recombinant Rabbit mAb (SDT‑235‑13) (S0B0061, Starter)
- Endocrine‑related ELISA Kits (Absin)
- Pituitary hormone and apoptosis research antibodies (Starter)
- Recombinant proteins for endocrine studies (UA)
- General buffers, diluents, and supporting reagents (Absin)
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ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high‑quality, reliable reagents and comprehensive solutions. Our specialized sub‑brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer‑centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights
