{"product_id":"slp-76-recombinant-rabbit-mab-sdt-3472-18-s0b3725","title":"SLP-76 Recombinant Rabbit mAb (SDT-3472-18）","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSLP-76\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein (SLP76); LCP2\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eImmunogen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant Protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eLocation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCytoplasm\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ13094\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eClone Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSDT-3472-18\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant mAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSandwich ELISA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProtein A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e2 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS pH7.4, 0.03% Proclin 300 \u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e12 months from date of receipt, 2 to 8 °C as supplied\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan style=\"color:#000000\"\u003eSLP-76 (SH2 domain-containing leukocyte protein of 76 \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003ekDa\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e) is a critical adaptor protein in the T cell receptor (TCR) signaling pathway, expressed predominantly in hematopoietic cells, especially T cells, natural killer cells, platelets, and mast cells. Structurally, it contains several functional modules: the N-terminal region has three tandem tyrosine-based motifs responsible for recruiting SH2 domain-containing downstream effector proteins such as Vav, \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eNck\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e, and \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eItk\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e; the central region contains a proline-rich motif that binds adaptor proteins like Gads to mediate interaction with LAT (linker for activation of T cells); and the C-terminal SH2 domain participates in feedback regulation of the signal complex. Upon TCR activation, SLP-76 is phosphorylated by ZAP-70 kinase, subsequently recruiting and activating downstream effectors including PLCγ1, Vav, PI3K, and Grb2, thereby initiating multiple critical signaling cascades such as calcium mobilization, the Ras-MAPK pathway, cytoskeletal rearrangement, and integrin activation, ultimately regulating T cell proliferation, differentiation, cytokine production, and immunological synapse formation. SLP-76 is indispensable for early T cell development, thymocyte positive selection, regulatory T cell function, and effector T cell responses; its deficiency leads to T cell developmental arrest, immunodeficiency, and severe autoimmunity. In platelets, SLP-76 participates in collagen-induced platelet activation and thrombus formation via the GPVI receptor. Furthermore, aberrant expression or mutations of SLP-76 are associated with immune dysregulation disorders (e.g., systemic lupus erythematosus), T-cell acute lymphoblastic leukemia, and certain primary immunodeficiencies. Owing to its nature as a central adaptor protein, SLP-76 is considered a potential regulatory node for T cell-mediated immunotherapy, holding significant research value in tumor immunity, autoimmune diseases, and antiviral immunity.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"0.5mg","offer_id":42968377032779,"sku":"S0B3725-0.5mg","price":835.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":42968377065547,"sku":"S0B3725-1mg","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/AntBioImage_37fc4abf-bfc6-49f5-aaf7-f649e0f65edf.png?v=1785730867","url":"https:\/\/www.antbioinc.com\/products\/slp-76-recombinant-rabbit-mab-sdt-3472-18-s0b3725","provider":"AntBio","version":"1.0","type":"link"}