{"product_id":"phospho-vegf-receptor-2-tyr1175-recombinant-rabbit-mab-s-3298-s0b6876","title":"Phospho-VEGF Receptor 2 (Tyr1175) Recombinant Rabbit mAb (S-3298)","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ePhospho-VEGF Receptor 2 (Tyr1175)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eVascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1 (FLK-1); Kinase insert domain receptor (KDR); Protein-tyrosine kinase receptor flk-1; CD309; FLK1; VEGFR2; KDR\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eLocation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCell membrane, Endoplasmic reticulum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP35968\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eClone Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eS-3298\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant mAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eWB\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHu, Ms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProtein A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e0.5 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e12 months from date of receipt \/ reconstitution, -20 °C as supplied\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eDilution\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 60%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eapplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003edilution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003especies\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWB\u003c\/td\u003e\n\u003ctd\u003e1:500-1:1000\u003c\/td\u003e\n\u003ctd\u003eHu, Ms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan style=\"color:#000000\"\u003ePhospho-VEGF Receptor 2 (Tyr1175) refers to the phosphorylated form of vascular endothelial growth factor receptor 2 (VEGFR-2) at tyrosine residue 1175, located within the kinase insert domain (KID) of the receptor, and is recognized as one of the most critical and characteristic phosphorylation sites for VEGFR-2-mediated downstream signaling. Upon stimulation by VEGF ligands (such as VEGF-A), VEGFR-2 undergoes dimerization and autophosphorylation; phosphorylation of Tyr1175 creates a highly conserved \"\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003epYXNXXV\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e\" binding motif that directly recruits and activates phospholipase \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eCγ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e (\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003ePLCγ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e), subsequently initiating downstream PLCγ-Ca²⁺-PKC and Ras-MAPK signaling cascades, which play central roles in regulating endothelial cell proliferation, migration, survival, and vascular permeability. Additionally, this site indirectly activates ERK1\/2 via the \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003ePLCγ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e-PKC pathway and participates in regulating \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eeNOS\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e activity and nitric oxide (NO) production, thereby influencing vascular tone. Compared to other tyrosine phosphorylation sites on VEGFR-2 (such as Tyr951, Tyr1059, and Tyr1214), Tyr1175 is considered the primary hub for pro-angiogenic signaling, with its phosphorylation level directly reflecting the activation status and functional signal output of VEGFR-2. Under pathological conditions, hyperphosphorylation of Tyr1175 is closely associated with diseases such as tumor angiogenesis, age-related macular degeneration, diabetic retinopathy, and atherosclerosis, driving pathological neovascularization and promoting disease progression.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"25µl","offer_id":43093642838091,"sku":"S0B6876-25µl","price":100.0,"currency_code":"USD","in_stock":true},{"title":"100µl","offer_id":43093642870859,"sku":"S0B6876-100µl","price":350.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/AntBioImage_e16fa4eb-f405-4ae5-98dd-69147c3525ae.png?v=1788195664","url":"https:\/\/www.antbioinc.com\/products\/phospho-vegf-receptor-2-tyr1175-recombinant-rabbit-mab-s-3298-s0b6876","provider":"AntBio","version":"1.0","type":"link"}