{"product_id":"ll-7-r-alphatslp-r-heterodimer-fc-chimerafc-chimera-protein-human-ua016180","title":"lL-7 R alpha\u0026TSLP R Heterodimer, Fc Chimera\u0026Fc Chimera Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIL7Ra, CD127, TSLP R, CRLF2, IL-XR, ILXR, p2RY8, CRLF2 fusion, TSLP receptor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP16871-1、Q9HC73-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eGlu 21-Asp 239 (lL-7 R alpha) with Human IgG1 Fc at the C-Terminus\u0026amp;Gln 23-Lys 231(TSLP R) with Human IgG1 Fc at the C-Terminus\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e60-100kDa (Reducing)\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman IgG1 Fc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, 5% trehalose, pH7.4\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e· 12 months from date of receipt,lyophilized powder stored at -20 to -80℃.\u003c\/p\u003e\n\u003cp\u003e· 3 months, -20 to -80℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· 1 week, 2 to 8℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· Please avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp style=\"margin-bottom: 0px;\"\u003e1. Lipworth B J, Han J K, Desrosiers M, et al. Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps[J]. New England Journal of Medicine, 2025, 392: 1178-1188.\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0px;\"\u003e2. Ebina-Shibuya R, Leonard W J. Role of thymic stromal lymphopoietin in allergy and beyond[J]. Nature Reviews Immunology, 2023, 23(1): 24-37.\u003c\/p\u003e\n\u003cp\u003e3. Liao C, Mennillo E, Kattah M G, et al. TSLP links intestinal nutrient sensing with amplification of the ILC2-tuft cell circuit[J]. Nature Immunology, 2025, 26(12): 2218-2226.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003eThe heterodimer formed by interleukin-7 receptor α (IL-7Rα, CD127) and the thymic stromal lymphopoietin receptor (TSLPR, CRLF2) constitutes the functional receptor complex for TSLP. Both chains are type I cytokine receptors: TSLPR provides the principal ligand-binding interface, whereas IL-7Rα is the shared signaling subunit. TSLP first engages TSLPR to form a binary pre-complex, which then recruits IL-7Rα to assemble a ternary complex; this triggers JAK1\/JAK2-mediated activation of STAT5, together with PI3K-AKT and MAPK signaling. The complex drives dendritic-cell maturation, Th2 polarization, ILC2 activation, and basophil\/mast-cell responses, placing it at the core of the epithelial alarmin axis. Clinically, tezepelumab—which blocks TSLP binding to this heterodimeric receptor—is approved for severe asthma and chronic rhinosinusitis with nasal polyps; inhaled anti-TSLP antibody fragments and bispecific antibodies are in development. In addition, CRLF2 dysregulation, including P2RY8::CRLF2 rearrangements, is a driver and therapeutic target in Ph-like acute lymphoblastic leukemia, highlighting the broader translational importance of this receptor complex.\u003cbr\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":67450014400587,"sku":"UA016180-25μg","price":210.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67450014433355,"sku":"UA016180-100μg","price":430.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67450014466123,"sku":"UA016180-500μg","price":1830.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":67450014498891,"sku":"UA016180-1mg","price":2730.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/e457bb40-790f-442c-b4f1-cbf3fca9a6b8_f7651163-12b5-4cfd-b235-9481087ac16d.png?v=1794387628","url":"https:\/\/www.antbioinc.com\/products\/ll-7-r-alphatslp-r-heterodimer-fc-chimerafc-chimera-protein-human-ua016180","provider":"AntBio","version":"1.0","type":"link"}