{"product_id":"lgr6-mfc-chimera-protein-human-ua016252","title":"LGR6 mFc Chimera Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLGR6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ9HBX8-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eAla25-Ala567 with Mouse IgG2a Fc Tag at the C-Terminus\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCHO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e100-130kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMouse IgG2a Fc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1. Zhao M, Zheng Z, Liu J, et al. LGR6 protects against myocardial ischemia-reperfusion injury via suppressing necroptosis[J]. Redox Biology, 2024, 78: 103400.\u003cbr\u003e2. Li F, Shi Y, Chen J, et al. LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis[J]. Journal of Translational Medicine, 2025, 23(1): 475.\u003cbr\u003e3. Chen Y, Li Y, Chen D, et al. Leucine-rich repeat-containing G-protein coupled receptor 6 protects cartilage from diabetes-driven degeneration by blocking ferroptosis: a new therapeutic target for osteoarthritis[J]. Antioxidants \u0026amp; Redox Signaling, 2026, 44(7-9): 357-372.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eLeucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) belongs to the LGR4\/5\/6 subfamily and serves as a receptor for R-spondins (RSPO1–4) and for the pro-resolving lipid mediator maresin 1 (MaR1). Structurally, LGR6 is a class A G protein-coupled receptor with seven transmembrane helices and a large extracellular N-terminal domain containing multiple leucine-rich repeats (LRRs). R-spondin binding to this ectodomain potentiates canonical Wnt\/β-catenin signaling by cooperating with RNF43\/ZNRF3, whereas MaR1 engagement activates Gs\/cAMP-dependent signaling. LGR6 marks adult epithelial stem cells in the skin, lung, mammary gland, kidney, intestine, taste buds, and nail, contributing to tissue homeostasis, injury repair, and inflammation resolution; it also exerts protective effects in the heart, cartilage, and intervertebral disc. Clinically, LGR6 is used as a stem-cell marker in regenerative medicine and is recognized as a prognostic biomarker and potential therapeutic target in cervical, triple-negative breast, lung, pancreatic, and esophageal cancers. The MaR1–LGR6 axis represents a promising intervention point for diabetic cardiomyopathy, osteoarthritis, intervertebral disc degeneration, and ischemia-reperfusion injury, while RSPO–LGR6-dependent Wnt signaling is an active area of drug development.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":67411264241739,"sku":"UA016252-25μg","price":265.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67411264274507,"sku":"UA016252-100μg","price":565.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67411264307275,"sku":"UA016252-500μg","price":1635.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/75c39b84be0d41319e8081d82c8b173d_e3aaed2f-b5bd-4b1d-b7be-4c5526a4cf6b.jpg?v=1793991621","url":"https:\/\/www.antbioinc.com\/products\/lgr6-mfc-chimera-protein-human-ua016252","provider":"AntBio","version":"1.0","type":"link"}