{"product_id":"invivopro-anti-mouse-pd-1-recombinant-mab-d265a-s0r0594","title":"InvivoPro anti-mouse PD-1 Recombinant mAb (D265A)","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ePD-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProgrammed cell death protein 1, mPD-1, CD279\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eLocation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCell membrane\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ02242\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eClone Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRMP1-14\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant mAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMouse IgG1 D265A, κ\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eIsotype Control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eS0B0788\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMutations\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eD265A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ein vivo blocking of PD-1\/PD-L signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProtein G\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e10 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026gt;95% (Determined by SEC-HPLC)  \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePathogen Tests\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003eEctromelia Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHantavirus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eK Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLactate Dehydrogenase-Elevating Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLymphocytic Choriomeningitis virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMouse Adenovirus\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e(MAD1,\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eMAD2): Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMouse Cytomegalovirus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMouse Hepatitis Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMouse Norovirus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMouse Parvovirus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMycoplasma \u003c\/span\u003e\u003cspan\u003ePulmonis\u003c\/span\u003e\u003cspan\u003e: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMouse Rotavirus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMinute Virus of Mice: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePneumonia Virus of Mice: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePolyoma Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eReovirus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSendai Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTheiler’s Murine Encephalomyelitis Virus: Negative\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS pH7.4, containing no preservative\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e2 to 8 °C for 2 weeks under sterile conditions;\u003cbr\u003e-20 °C for 3 months under sterile conditions; \u003cbr\u003e-80 °C for 24 months under sterile conditions.\u003cbr\u003ePlease avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eProgrammed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"1mg","offer_id":67307364581451,"sku":"S0R0594-1mg","price":200.0,"currency_code":"USD","in_stock":true},{"title":"5mg","offer_id":67307364614219,"sku":"S0R0594-5mg","price":770.0,"currency_code":"USD","in_stock":true},{"title":"25mg","offer_id":67307364646987,"sku":"S0R0594-25mg","price":2635.0,"currency_code":"USD","in_stock":true},{"title":"50mg","offer_id":67307364679755,"sku":"S0R0594-50mg","price":3920.0,"currency_code":"USD","in_stock":true},{"title":"100mg","offer_id":67307364712523,"sku":"S0R0594-100mg","price":5470.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/AntBioImage_75f63ede-ff32-4318-b71f-44d67a31cbef.png?v=1792782006","url":"https:\/\/www.antbioinc.com\/products\/invivopro-anti-mouse-pd-1-recombinant-mab-d265a-s0r0594","provider":"AntBio","version":"1.0","type":"link"}