{"product_id":"il-27-his-tag-protein-human-ua040585","title":"IL-27 His Tag Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIL-27 p28 subunit, IL-27 subunit alpha, IL27, IL-27, IL27A, IL-27-A, IL27-A, IL27p28,  interleukin 27, interleukin-27 subunit alpha, MGC71873, p28IL-27A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eArg21-Lys229 (Q14213)\u003cbr\u003ePhe29-Pro243 (Q8NEV9)\u003cbr\u003eLinked by linker and followed by C-terminal His Tag\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e58-62 kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026gt;90% by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e20mM HEPES, 150mM NaCl, 0.05% CHAPS, 1mM EDTA, 5% Trehalose, pH7.0\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003e·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e·3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e·1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e·Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eAnnu Rev Immunol. 2015:33:417-43.\u003cbr\u003eJ Neuroinflammation. 2022 Sep 1;19(1):212.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eInterleukin-27 (IL-27) is a heterodimeric cytokine that belongs to the IL-6\/IL-12 family of long type I cytokines. It is composed of two subunits: EBI3 (EBV-induced gene 3), which is related to the p40 subunit of IL-12 and IL-23, and p28, which is related to the p35 chain of IL-12. IL-27 is primarily produced by monocytes, endothelial cells, and dendritic cells. It signals through a heterodimeric receptor complex composed of WSX-1 (TCCR) and gp130. IL-27 has both anti-inflammatory and pro-inflammatory properties. As an anti-inflammatory cytokine, it induces a general negative feedback program that limits T and NK-T cell activity. During the onset of infection, IL-27 induces an IL-12 receptor on naïve CD4+ T cells, making them susceptible to subsequent IL-12 activity and possible Th1 development.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"10μg","offer_id":43068885991499,"sku":"UA040585-10μg","price":150.0,"currency_code":"USD","in_stock":true},{"title":"50μg","offer_id":43068886024267,"sku":"UA040585-50μg","price":305.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43068886057035,"sku":"UA040585-100μg","price":550.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43068886089803,"sku":"UA040585-500μg","price":1915.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43068886122571,"sku":"UA040585-1mg","price":3060.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/162795072be14064bfd3edcf8485b2e0_1c64b9e6-6e86-43e4-94a0-cc917112dd94.png?v=1787648698","url":"https:\/\/www.antbioinc.com\/products\/il-27-his-tag-protein-human-ua040585","provider":"AntBio","version":"1.0","type":"link"}