{"product_id":"il-27-his-tag-protein-cynomolgus-ua040571","title":"IL-27 His Tag Protein, Cynomolgus","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCynomolgus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eInterleukin 27, IL27, IL-27\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eQ14213.2 EBI-3 Arg21-Lys229\u003cbr\u003eQ8NEV9.2 p28 Phe29-Pro243 \u003cbr\u003eLinked by linker and followed by C-terminal His\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e58-62 kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026gt;95% by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, 5% trehalose, pH7.4\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003cbr\u003e·3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003cbr\u003e·1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003cbr\u003e·Please avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eImmunity, 16(6), 779-790.\u003cbr\u003eJournal of Experimental Medicine, 221(12).\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eInterleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family. It is composed of two subunits, Epstein-Barr virus-induced gene 3 (EBI3) and p28, and signals through a receptor complex formed by WSX-1 (also known as TCCR or IL-27Rα) and gp130.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIL-27 is produced primarily by antigen-presenting cells (APCs), such as monocytes, dendritic cells, and macrophages, upon activation of pattern recognition receptors. The cynomolgus monkey (Macaca fascicularis) IL-27 protein shares a high degree of amino acid identity with its human ortholog (e.g., 92% for the p28 subunit), enabling the translation of findings from preclinical models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe biological effects of IL-27 are pleiotropic and context-dependent, integrating both pro-inflammatory and anti-inflammatory functions. It plays a key role in the early induction of Th1 differentiation and also exerts immunosuppressive effects. The specific outcome of IL-27 signaling—whether it promotes or resolves inflammation—is determined by the cellular context, disease state, and infection phase.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"10μg","offer_id":43045169528907,"sku":"UA040571-10μg","price":150.0,"currency_code":"USD","in_stock":true},{"title":"50μg","offer_id":43045169561675,"sku":"UA040571-50μg","price":305.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43045169594443,"sku":"UA040571-100μg","price":550.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43045169627211,"sku":"UA040571-500μg","price":1915.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43045169659979,"sku":"UA040571-1mg","price":3060.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/aebbd4c88c0b409db1bcf46f1f0db20f.png?v=1786953606","url":"https:\/\/www.antbioinc.com\/products\/il-27-his-tag-protein-cynomolgus-ua040571","provider":"AntBio","version":"1.0","type":"link"}