{"product_id":"il-2-rcd132-fc-chimera-protein-human-ua011294","title":"IL-2 Rγ\/CD132 Fc Chimera Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIL-2 receptor subunit gamma, IL2RG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP31785-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eLeu23-Asn254 with hIgG1 Fc Tag at the C-Terminus\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e70-100kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞95% by SDS-PAGE\u0026amp;HPLC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003cbr\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003cbr\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003cbr\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1.Kim JY, Mayatepek E, Seyfarth J, Jacobsen M. High common-γ cytokine receptor levels promote expression of Interleukin-2\/Interleukin-7 receptor α-chains with implications on T-cell differentiation and function. Immunology. 2024 Sep;173(1):93-105.\u003cbr\u003e2.Andreu-Ballester JC, Hurtado-Marcos C, García-Ballesteros C, Pérez-Griera J, Izquierdo F, Ollero D, Jiménez A, Gil-Borrás R, Llombart-Cussac A, López-Chuliá F, Cuéllar C. Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease. World J Gastroenterol. 2025 Mar 28;31(12):97120. \u003cbr\u003e3.Montorfani J, Hatterer E, Chatel L, Lesnier A, Viandier A, Daubeuf B, Nouveau L, Malinge P, Calloud S, Masternak K, Ferlin W, Fischer N, Jandus C, Shang L. Selective activation of interleukin-2\/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies. J Immunother Cancer. 2025 Mar 25;13(3):e010650. \u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eIL-2 Rγ\/CD132 is a transmembrane protein belonging to the type I cytokine receptor family, characterized by a highly conserved extracellular WSXWS motif, a transmembrane region, and an intracellular domain containing Box1\/Box2 motifs. It serves as the shared signaling chain for six cytokines: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Through its intracellular domain, it couples with signaling molecules such as JAK3 and STAT5, playing an indispensable core role in T\/NK cell development, lymphocyte homeostasis, and immune regulation. The clinical significance of this molecule is substantial—mutations in its gene cause X-linked severe combined immunodeficiency (X-SCID). Therapeutic strategies targeting this molecule have been translated in three key ways: gene therapy encoding γc (e.g., Strimvelis) has received clinical approval; CD132-targeting bispecific antibodies selectively activate the common receptor complex within the tumor microenvironment to achieve anti-tumor immunity while avoiding systemic toxicity; and engineered IL-2\/antibody biased complexes modulate CD132-dependent signaling preferences to expand regulatory T cells for transplant tolerance and autoimmune disease treatment.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":43096034312267,"sku":"UA011294-25μg","price":185.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43096034345035,"sku":"UA011294-100μg","price":370.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43096034377803,"sku":"UA011294-500μg","price":1025.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43096034410571,"sku":"UA011294-1mg","price":1540.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/2ff8fec4b60444ac87716e1f1512575f.png?v=1788228130","url":"https:\/\/www.antbioinc.com\/products\/il-2-rcd132-fc-chimera-protein-human-ua011294","provider":"AntBio","version":"1.0","type":"link"}