{"product_id":"il-17-rail-17-rc-heterodimer-histag-free-protein-human-ua016203","title":"IL-17 RA\u0026IL-17 RC Heterodimer His\u0026Tag Free Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIL-17 RA\u0026amp;IL-17 RC, CD217, IL-17RA, IL-17 receptor C, IL-17RL, IL-17RC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ96F46-1、NP_703190.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eLeu 33-Trp 320 (IL-17 RA) with His Tag at the C-Terminus;\u003cbr\u003eLeu 21-His 465(IL-17 RC) with No Tag\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e60-90kDa\u0026amp;100-130kDa (Reducing)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞95% by SDS-PAGE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag, No Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1. WILSON S C, CAVENEY N A, YEN M, et al. Organizing structural principles of the IL-17 ligand-receptor axis[J]. Nature, 2022, 609: 622-629.\u003cbr\u003e2. GOEPFERT A, LEHMANN S, BLANK J, et al. Structural analysis reveals that the cytokine IL-17F forms a homodimeric complex with receptor IL-17RC to drive IL-17RA-independent signaling[J]. Immunity, 2020, 52(3): 499-512.e5.\u003cbr\u003e3. GOEPFERT A, LEHMANN S, WERDER J, et al. IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling[J]. Cell Reports, 2022, 41(9): 111751.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eIL-17RA and IL-17RC serve as the principal receptor subunits for IL-17 family cytokines, forming a classic heterodimeric signaling complex. Structurally, both receptors contain fibronectin type III domains in their extracellular regions and engage IL-17A\/F ligands via a tip-to-tip assembly mode to form ternary complexes, which further organize into 2:2:2 hexameric signalosomes to amplify downstream signaling. Functionally, this receptor complex drives pro-inflammatory responses through the activation of NF-\u003c\/span\u003e\u003cspan\u003eκ\u003c\/span\u003e\u003cspan\u003eB and MAPK pathways, playing a pivotal role in the pathogenesis of autoimmune diseases such as psoriasis and ankylosing spondylitis. Clinically, brodalumab (anti-IL-17RA) and anti-IL-17A monoclonal antibodies targeting this axis have been widely applied in the treatment of inflammatory disorders, while small-molecule inhibitors are currently under active development.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":43089700126795,"sku":"UA016203-25μg","price":215.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43089700159563,"sku":"UA016203-100μg","price":430.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43089700192331,"sku":"UA016203-500μg","price":1205.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43089700225099,"sku":"UA016203-1mg","price":1920.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/c15de42eb106441e87db01f6c80f72ff.png?v=1788109393","url":"https:\/\/www.antbioinc.com\/products\/il-17-rail-17-rc-heterodimer-histag-free-protein-human-ua016203","provider":"AntBio","version":"1.0","type":"link"}