{"product_id":"il-15ra-his-tag-protein-macaca-fascicularis-ua016254","title":"IL-15RA His Tag Protein, Macaca fascicularis","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMacaca fascicularis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIL-15 R alpha, CD215, IL-15R-alpha, IL15RA\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eXP_015311004.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eIIe31-Thr204 with His Tag at the C-Terminus\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e50-60kDa (Reducing)\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e· 12 months from date of receipt,lyophilized powder stored at -20 to -80℃.\u003c\/p\u003e\n\u003cp\u003e· 3 months, -20 to -80℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· 1 week, 2 to 8℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· Please avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp style=\"margin-bottom: 0px;\"\u003e1. Amaria R N, Chesney J A, Betof A S, et al. Regulatable membrane-bound IL-15 engineered TIL cell therapy for immune checkpoint inhibitor-resistant advanced melanoma: pooled analysis of phase 1 and 1\/2 trials[J]. Nature Medicine, 2026. \u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0px;\"\u003e2. Rafei H, Basar R, Acharya S, et al. CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells[J]. Nature, 2025, 643(8073): 1076-1086.\u003c\/p\u003e\n\u003cp\u003e3. Choudhary N, Faiyazuddin M, Kamal R, et al. IL-15 superagonists for reprogramming the immunosuppressive microenvironment in gastrointestinal adenocarcinomas[J]. Cancer Letters, 2026, 659: 218780.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003eInterleukin-15 receptor α (IL-15Rα), also known as CD215, is the private, high-affinity receptor subunit for IL-15. It is a type I transmembrane glycoprotein whose extracellular region contains a single sushi domain that binds IL-15 with picomolar affinity. When co-expressed with IL-15, IL-15Rα forms an IL-15\/IL-15Rα complex that is displayed on the cell surface and trans-presented to neighboring cells expressing the IL-2Rβ\/γc heterodimer; metalloprotease cleavage additionally generates soluble IL-15Rα. IL-15Rα is expressed mainly by dendritic cells, monocytes\/macrophages, and stromal cells. It does not signal directly; rather, it binds, stabilizes, traffics, and presents IL-15, while signal transduction through IL-2Rβ\/γc activates JAK1\/JAK3–STAT5, PI3K-AKT, and MAPK pathways that drive the development, proliferation, survival, and cytotoxic function of NK cells and memory CD8⁺ T cells. Clinically, IL-15\/IL-15Rα complexes and the IL-15 superagonist N-803 (nogapendekin alfa inbakicept) have been approved for BCG-unresponsive non-muscle-invasive bladder cancer, and IL-15Rα-based constructs are widely explored in armored CAR-NK\/CAR-T cells, TIL therapy, chronic infections, and autoimmune disease.\u003cbr\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":67472026697803,"sku":"UA016254-25μg","price":180.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67472026730571,"sku":"UA016254-100μg","price":480.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67472026763339,"sku":"UA016254-500μg","price":1545.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":67472026796107,"sku":"UA016254-1mg","price":2310.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/170101f9-7abd-40c3-a57c-96fc6155c769.png?v=1794567661","url":"https:\/\/www.antbioinc.com\/products\/il-15ra-his-tag-protein-macaca-fascicularis-ua016254","provider":"AntBio","version":"1.0","type":"link"}