{"product_id":"il-11-his-tag-protein-cynomolgus-ua016011","title":"IL-11 His Tag Protein, Cynomolgus","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCynomolgus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eInterleukin-11, IL11\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP20808\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePro 22 - Leu 199 with His Tag at the N-Terminus\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e20-26kDa (Reducing)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞95% by SDS-PAGE,\u0026gt; 90% by HPLC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, PH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003cbr\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003cbr\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003cbr\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1.Li X, Pang PS, Zhang S, Ru L, Yuan Z, Liu R, Choo QL, Wang Q, Song J, Xu Q, Zhang K, Yu KM, Xu Z. Immunogenicity and toxicokinetics assessment of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys. Life Sci. 2020 Oct 15;259:118244. \u003cbr\u003e2.Yu KM, Lau JY, Fok M, Yeung YK, Fok SP, Zhang S, Ye P, Zhang K, Li X, Li J, Xu Q, Wong WT, Choo QL. Preclinical evaluation of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys. Toxicol Appl Pharmacol. 2018 Mar 1;342:39-49. \u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eIL-11 (Interleukin-11) is a 178-amino-acid four-helix bundle cytokine belonging to the IL-6 family, which activates the JAK\/STAT3 signaling pathway by binding to the specific IL-11 receptor alpha chain (IL-11Rα) and recruiting the gp130 co-receptor to form a heterodimeric complex. Structurally, IL-11 consists of four antiparallel α-helices (A-D) that constitute the typical cytokine fold, with helices A and C, as well as B and D, forming two pairs of parallel arrangements connected by two long loop regions—this structural feature determines its high-affinity binding to the receptor. Functionally, IL-11 exhibits pleiotropic biological activities: as a hematopoietic growth factor, it stimulates megakaryocyte maturation and thrombopoiesis; in mucosal protection, it promotes intestinal epithelial cell proliferation and repair; it also possesses anti-inflammatory properties by suppressing pro-inflammatory cytokine production from macrophages; additionally, it participates in bone metabolism regulation, neuroprotection, and reproductive processes. Clinically, recombinant human IL-11 (Oprelvekin) was the first approved therapeutic agent for chemotherapy-induced thrombocytopenia, significantly reducing bleeding risks and transfusion requirements in cancer patients; recent studies have revealed that IL-11 is overexpressed in pulmonary fibrosis, rheumatoid arthritis, and various malignancies (such as gastric and colorectal cancers), where it promotes tissue fibrosis and tumor invasion and metastasis, thereby establishing IL-11 signaling inhibition as a potential new therapeutic target for fibrotic diseases and cancer, with relevant antibody drugs currently under clinical development.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":42302223777867,"sku":null,"price":215.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":42302223810635,"sku":null,"price":430.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":42302223843403,"sku":null,"price":1205.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":42302223876171,"sku":null,"price":1920.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/AntBioImage_5dc259cd-968e-42f6-be33-08a9a7bde896.png?v=1776073928","url":"https:\/\/www.antbioinc.com\/products\/il-11-his-tag-protein-cynomolgus-ua016011","provider":"AntBio","version":"1.0","type":"link"}