{"product_id":"il-10-protein-mouse-ua040528","title":"IL-10 Protein, Mouse","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eInterleukin-10, IL-10, Cytokine synthesis inhibitory factor (CSIF)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP18893\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eSer19-Ser178\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e14-18 kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026gt;95% by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eNo Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003cbr\u003e·3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003cbr\u003e·1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003cbr\u003e·Please avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eNat Nanotechnol. 2025 Oct;20(10):1526-1538.\u003cbr\u003eImmunity. 2025 May 13;58(5):1306-1326.e7.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eInterleukin-10 (IL-10) is a key immunoregulatory cytokine critical for maintaining immune homeostasis and preventing pathological inflammation in mice. Produced by diverse immune cells including T cells, B cells, macrophages, dendritic cells, and innate lymphoid cells (ILCs), IL-10 exerts its pleiotropic effects primarily through the IL-10 receptor complex (IL-10R) and downstream JAK-STAT3 signaling. Mouse models have been instrumental in defining IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10's non\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003eredundant functions: global IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 knockout (IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10^(−\/−)) mice develop spontaneous, microbiota\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003edependent colitis, establishing IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 as a central guardian of intestinal immune homeostasis. Conversely, transgenic and conditional knockout mice have revealed cell\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003etype\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003especific contributions of IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 in regulating inflammation in the lungs, brain, and joint tissues.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMajor applications of mouse IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 include: (1) inflammatory bowel disease (IBD) research, where IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10^(−\/−) mice serve as a widely accepted model for Crohn's disease, enabling preclinical evaluation of microbiota\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003ebased and immune\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003emodulating therapies; (2) cancer immunotherapy, where engineered IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 expression—such as IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003emRNA nanoparticles—promotes cytotoxic T cell infiltration and synergizes with immune checkpoint blockade to achieve durable antitumor immunity; (3) autoimmune and inflammatory disease studies, including rheumatoid arthritis, multiple sclerosis, and osteoarthritis, where IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 signaling limits tissue damage and suppresses pathogenic immune responses; and (4) neuroinflammation research, using IL\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003e10 knockout mice to elucidate microglial resolution mechanisms in the central nervous system.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"10μg","offer_id":43027998769227,"sku":"UA040528-10μg","price":175.0,"currency_code":"USD","in_stock":true},{"title":"50μg","offer_id":43027998801995,"sku":"UA040528-50μg","price":450.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43027998834763,"sku":"UA040528-100μg","price":715.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43027998867531,"sku":"UA040528-500μg","price":1970.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43027998900299,"sku":"UA040528-1mg","price":3150.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/942796cc-fb14-4ac2-88ed-2608b52aebb1.png?v=1786435207","url":"https:\/\/www.antbioinc.com\/products\/il-10-protein-mouse-ua040528","provider":"AntBio","version":"1.0","type":"link"}