{"product_id":"human-sostsclerostin-protein-his-tag-s0a9070","title":"Human SOST\/Sclerostin Protein, His Tag","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSclerostin, SOST, UNQ2976\/PRO7455\/PRO7476\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ9BQB4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eProtein sequence (Q9BQB4, Gln24-Try213, with C-His Tag) QGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ePredicted MW: 23.2 kDaObserved MW: 25-35 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞90% by SDS-PAGE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ewith C-His Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eLyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eReconstitute no more than 1 mg\/mL according to the size in deionized water after rapid centrifugation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e12 months from date of receipt, -20 to -70 °C as supplied.\u003cbr\u003e6 months, -20 to -70 °C under sterile conditions after reconstitution.\u003cbr\u003e1 week, 2 to 8 °C under sterile conditions after reconstitution.\u003cbr\u003ePlease avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eSclerostin, encoded by SOST, is a secreted glycoprotein predominantly produced by osteocytes and a key negative regulator of bone formation. It binds LRP5\/6 to antagonize canonical \u003c\/span\u003e\u003cspan\u003eWnt\u003c\/span\u003e\u003cspan\u003e\/β-catenin signaling, thereby suppressing osteoblast differentiation, proliferation, and matrix mineralization. Genetic studies of \u003c\/span\u003e\u003cspan\u003esclerosteosis\u003c\/span\u003e\u003cspan\u003e and van \u003c\/span\u003e\u003cspan\u003eBuchem\u003c\/span\u003e\u003cspan\u003e disease, caused by SOST loss-of-function mutations, revealed a striking high-bone-mass phenotype, establishing sclerostin as a critical therapeutic target. Preclinical and clinical studies demonstrated that sclerostin inhibition, notably via \u003c\/span\u003e\u003cspan\u003eromosozumab\u003c\/span\u003e\u003cspan\u003e, rapidly increases bone formation and reduces fracture risk. Emerging research further implicates sclerostin in vascular calcification, chronic kidney disease, and cancer-associated bone metastasis, suggesting broader roles beyond skeletal homeostasis.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"10μg","offer_id":67233135722571,"sku":"S0A9070-10μg","price":110.0,"currency_code":"USD","in_stock":true},{"title":"25μg","offer_id":67233135755339,"sku":"S0A9070-25μg","price":210.0,"currency_code":"USD","in_stock":true},{"title":"50μg","offer_id":67233135788107,"sku":"S0A9070-50μg","price":330.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67233135820875,"sku":"S0A9070-100μg","price":530.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67233135853643,"sku":"S0A9070-500μg","price":2150.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":67233135886411,"sku":"S0A9070-1mg","price":3120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/68eb439dd3244e15b369eba85f2cc4db.jpg?v=1791936114","url":"https:\/\/www.antbioinc.com\/products\/human-sostsclerostin-protein-his-tag-s0a9070","provider":"AntBio","version":"1.0","type":"link"}