{"product_id":"human-pd-l1-onestep-elisa-kit-s0c3228","title":"Human PD-L1 OneStep ELISA Kit","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ePD-L1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eImmunogen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant Protein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant mAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHu\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProtein A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e12 months from date of receipt \/ reconstitution, 2 to 8°C as supplied.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eKit\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePrecision\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIntra-assay: 5.5%；\u003cbr\u003eInter-assay: 6.9%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSample type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSerum; EDTA Plasma, Citrate Plasma; Cell Culture Supernatant\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAssay type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSandwich (quantitative)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e2.95 pg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eRange\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e12.5 pg\/mL – 800 pg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eRecovery\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eSerum: 105%\u003cbr\u003eEDTA Plasma: 103%\u003cbr\u003eCitrate plasma: 94%\u003cbr\u003eCell Culture Supernatant: 120%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAssay time\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e60 minutes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies reactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHu\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eHuman PD-L1 (programmed death-ligand 1) is a 290-amino acid type I transmembrane glycoprotein encoded by the CD274 gene, also known as B7-H1 or CD274. It is a member of the B7 family of immune regulatory molecules and consists of a signal peptide (residues 1–18), an extracellular domain (residues 19–238) containing IgV-like and IgC-like subdomains, a transmembrane region (residues 239–259), and a short cytoplasmic domain of approximately 31 amino acids. The extracellular IgV domain serves as the primary binding interface for its receptor PD-1, mediating a large hydrophobic interaction surface that stabilizes the ligand-receptor complex. As a key immune checkpoint molecule, PD-L1 functions by binding to PD-1 on activated T cells, delivering inhibitory signals that suppress T cell proliferation and effector function, thereby contributing to immune tolerance and preventing excessive immune-mediated tissue damage. Unlike constitutively expressed surface markers, PD-L1 expression is highly inducible and upregulated in response to inflammatory cytokines such as interferon-γ and tumor necrosis factor-α, as well as under conditions of persistent antigenic stimulation in the tumor microenvironment. In oncology, PD-L1 expression in tumor tissues and immune cells has become an established biomarker for predicting the efficacy of immune checkpoint inhibitors, with higher expression levels generally correlating with greater clinical benefit from anti-PD-1\/PD-L1 therapies. Researchers commonly assess PD-L1 expression by immunohistochemistry using standardized scoring systems such as the tumor proportion score or combined positive score to guide patient stratification in cancer immunotherapy. Because it can be reliably detected in formalin-fixed paraffin-embedded tumor specimens, PD-L1 serves as a practical and sensitive indicator for identifying patients likely to respond to checkpoint blockade. Thus, it plays a central role in both the mechanistic understanding of tumor immune evasion and the clinical evaluation of immunotherapeutic interventions in human cancer.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"1x24T","offer_id":43212635963467,"sku":"S0C3228-1x24T","price":160.0,"currency_code":"USD","in_stock":true},{"title":"1x48T","offer_id":43212635996235,"sku":"S0C3228-1x48T","price":285.0,"currency_code":"USD","in_stock":true},{"title":"1x96T","offer_id":43212636029003,"sku":"S0C3228-1x96T","price":700.0,"currency_code":"USD","in_stock":true},{"title":"5x96T","offer_id":43212636061771,"sku":"S0C3228-5x96T","price":3500.0,"currency_code":"USD","in_stock":true},{"title":"10x96T","offer_id":43212636094539,"sku":"S0C3228-10x96T","price":7000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/466d290d98b54b0baa64187141e38e86_381a99df-fe4c-4ed2-a17a-277f198bf96d.jpg?v=1789718483","url":"https:\/\/www.antbioinc.com\/products\/human-pd-l1-onestep-elisa-kit-s0c3228","provider":"AntBio","version":"1.0","type":"link"}