{"product_id":"gitr-ligandtnfsf18-trimer-his-tag-protein-human-ua016231","title":"GITR Ligand\/TNFSF18 Trimer His Tag Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAITRL, TL6, hGITRL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAAH69319.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eGln50-Ser177with His Tag at the N-Terminus\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e45-60kDa (Reducing)\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;0.1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e· 12 months from date of receipt,lyophilized powder stored at -20 to -80℃.\u003c\/p\u003e\n\u003cp\u003e· 3 months, -20 to -80℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· 1 week, 2 to 8℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· Please avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp style=\"margin-bottom: 0px;\"\u003e1. Avraham Y, Barth N, Yair Bar-On T, et al. Fc-optimized GITR antibody enhances a CD4 T cell-dendritic cell crosstalk to promote antitumor immunity[J]. Nature Cancer, 2026, 7(9): 1419-1435. \u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0px;\"\u003e2. You W, Hu C, Zhang Y, et al. Reinvigorating COTL1^high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours[J]. Nature Cell Biology, 2026, 28(5): 957-971.\u003c\/p\u003e\n\u003cp\u003e3. Jung D, Goh A R, Kim K Y, et al. Enhanced anti-tumor efficacy of tumor-infiltrating lymphocytes by GITR agonist in ovarian cancer[J]. Frontiers in Immunology, 2025, 16: 167084.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003eGITR ligand (GITRL), also known as TNFSF18, AITRL, or TL6, is a member of the tumor necrosis factor superfamily and the cognate ligand of the costimulatory receptor GITR (TNFRSF18\/CD357). GITRL is a type II transmembrane glycoprotein whose extracellular region adopts the characteristic TNF homology β-sandwich fold; in humans it assembles predominantly as a homotrimer. Trimeric GITRL engages GITR, inducing receptor clustering and signaling through TRAF2\/5–NF-κB and MAPK pathways, while metalloprotease cleavage releases soluble GITRL. GITRL is expressed mainly on dendritic cells, macrophages, B cells, and endothelial cells. It promotes the proliferation, activation, and survival of CD4⁺ and CD8⁺ effector T cells while attenuating regulatory T-cell suppression, placing the GITRL–GITR axis at a central node of antitumor and autoimmune regulation. Clinically, GITR agonist antibodies, multimeric GITRL constructs, anti-PD-1–GITRL bispecific molecules, and GITRL-armored CAR-NK\/CAR-T cells are being developed for cancer immunotherapy. Monotherapy has shown limited efficacy in early trials, so combination with PD-1 or CTLA-4 blockade is now the main strategy, with additional potential in autoimmune disease and HIV reservoir reactivation.\u003cbr\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":67450014531659,"sku":"UA016231-25μg","price":195.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67450014564427,"sku":"UA016231-100μg","price":380.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67450014597195,"sku":"UA016231-500μg","price":1545.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":67450014629963,"sku":"UA016231-1mg","price":2310.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/0082c4e2-cc9a-4dff-a112-18eb63a2d6d0_1e69d94c-d173-4e63-b7c3-07e6258df2b6.png?v=1794387619","url":"https:\/\/www.antbioinc.com\/products\/gitr-ligandtnfsf18-trimer-his-tag-protein-human-ua016231","provider":"AntBio","version":"1.0","type":"link"}