{"product_id":"dr3tnfrsf25-his-tag-protein-human-ua016194","title":"DR3\/TNFRSF25 His Tag Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eTNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, Apo-3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ93038-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eGln25-Gln199 with His Tag at the C-Terminus\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCHO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e35-40kDa (Reducing)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞95% by SDS-PAGE\u0026amp;HPLC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1.Menghini P, Buttó LF, Gomez-Nguyen A, Aladyshkina N, Buela KA, Osme A, Chan R, Wargo HL, De Santis S, Bamias G, Pizarro TT, Cominelli F. Tumor Necrosis Factor-Like Ligand 1A\/Death Receptor 3 Signaling Regulates the Generation of Pathogenic T Helper 9 Cells in Experimental Crohn's Disease. Gastroenterology. 2025 Oct;169(5):892-908.\u003cbr\u003e2.Menghini P, Butto L, Gomez-Nguyen A, Aladyshkina N, Buela KA, Osme A, Chan R, Bamias G, Pizarro TT, Cominelli F. TL1A\/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease. bioRxiv [Preprint]. 2024 Feb 12:2024.02.09.579684. \u003cbr\u003e3.Sia J, Lee B, Oon HH. Unravelling the TL1A-DR3 axis in Hidradenitis suppurativa. Front Immunol. 2026 Apr 22;17:1837120. \u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eDR3 (TNFRSF25), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein characterized by an extracellular cysteine-rich domain that specifically binds its unique ligand TL1A (TNFSF15) and an intracellular death domain capable of recruiting the adaptor protein TRADD to activate downstream NF-κB and MAPK signaling pathways. Functionally, DR3 exerts bidirectional immunomodulatory effects: it maintains Foxp3⁺ regulatory T cell homeostasis to restrain excessive inflammation, while simultaneously promoting pathogenic Th17 differentiation and inducing fibroblast activation, contributing to intestinal fibrosis; genetic polymorphisms in its ligand-encoding gene TNFSF15 have been strongly associated with susceptibility to Crohn's disease and rheumatoid arthritis. Clinically, DR3 agonists are being developed for the treatment of autoimmune diseases and the prevention of graft-versus-host disease, whereas blocking antibodies show therapeutic promise in inflammatory bowel disease and fibrotic complications; moreover, enrichment of DR3⁺ Tregs in the tumor microenvironment correlates with immune evasion and poor prognosis, positioning DR3 as a multifaceted therapeutic target across autoimmunity, transplantation, oncology, and infectious diseases.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":43057574608971,"sku":"UA016194-25μg","price":185.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43057574641739,"sku":"UA016194-100μg","price":370.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43057574674507,"sku":"UA016194-500μg","price":1295.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43057574707275,"sku":"UA016194-1mg","price":1940.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/be7d0bb972804710acda8ff314713a1e.jpg?v=1787306408","url":"https:\/\/www.antbioinc.com\/products\/dr3tnfrsf25-his-tag-protein-human-ua016194","provider":"AntBio","version":"1.0","type":"link"}