{"product_id":"clec5a-his-tag-protein-cynomolgus-ua016114","title":"CLEC5A His Tag Protein, Cynomolgus","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCynomolgus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCLECSF5, superfamilymember 5, C-type lectin domain family 5, member A, MDL1, MDL-1, DAP12-associating lectin 1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eXP_005551048.3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePro28-Arg188 with His Tag at the C-Terminus\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e40-55kDa (Reducing)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞95% by SDS-PAGE \u0026amp; HPLC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHis Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1. ZHANG T N, HUANG X M, GOODWIN J E, et al. Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis[J]. Science Advances, 2025, 11(24): eadt7589. \u003cbr\u003e2. HOU L, et al. C-type lectin domain family 5 member A-mediated activation of macrophages via a bispecific antibody enhances anti-HER2 therapy[J]. Journal for ImmunoTherapy of Cancer, 2026, 14(4): e014799.\u003cbr\u003e3. CHEN R, WU W, CHEN S Y, et al. A pan-cancer analysis reveals CLEC5A as a biomarker for cancer immunity and prognosis[J]. Frontiers in Immunology, 2022, 13: 831542.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eCLEC5A, also known as C-type lectin domain family 5 member A, is a transmembrane receptor coupled to the adaptor protein DAP12 (DNAX-activating protein of 12 kDa) and belongs to the C-type lectin-like receptor superfamily. Its extracellular region contains a single C-type lectin-like domain (CTLD), which is connected via a transmembrane segment to the ITAM motif of intracellular DAP12, mediating downstream signal transduction. CLEC5A is predominantly expressed on myeloid immune cells, including monocytes\/macrophages, dendritic cells, and neutrophils, serving as a critical pattern recognition receptor (PRR) for the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Functionally, CLEC5A participates in the regulation of inflammatory responses, macrophage polarization, and the tumor immune microenvironment, playing pivotal roles in sepsis, viral infections, and tumor progression. In recent years, CLEC5A has garnered significant attention as a novel immunotherapeutic target, with bispecific antibodies, antibody-drug conjugates (ADCs), and small-molecule inhibitors actively under development, demonstrating promising clinical application prospects in the treatment of solid tumors such as breast cancer and osteosarcoma, as well as sepsis-associated lung injury.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":43096733286475,"sku":"UA016114-25μg","price":295.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43096733319243,"sku":"UA016114-100μg","price":585.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43096733352011,"sku":"UA016114-500μg","price":1920.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43096733384779,"sku":"UA016114-1mg","price":2880.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/d602bb4f0dec4d269638a1f113f9b3f0.jpg?v=1788242506","url":"https:\/\/www.antbioinc.com\/products\/clec5a-his-tag-protein-cynomolgus-ua016114","provider":"AntBio","version":"1.0","type":"link"}