{"product_id":"cd3-epsilon-fchis-tag-protein-cynomolgus-ua016235","title":"CD3 epsilon Fc\u0026His Tag Protein, Cynomolgus","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCynomolgus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCD3 epsilon, CD3E\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ95LI5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eGln 22 - Asp 117 (CD3E) with human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e40-55kDa (Reducing)  \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003e·\u003c\/span\u003e\u003cspan\u003e 12 months from date of receipt, lyophilized powder stored at -20 to -80\u003c\/span\u003e\u003cspan\u003e℃\u003c\/span\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e·\u003c\/span\u003e\u003cspan\u003e 3 months, -20 to -80\u003c\/span\u003e\u003cspan\u003e℃\u003c\/span\u003e\u003cspan\u003e under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e·\u003c\/span\u003e\u003cspan\u003e 1 week, 2 to 8\u003c\/span\u003e\u003cspan\u003e℃\u003c\/span\u003e\u003cspan\u003e under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e·\u003c\/span\u003e\u003cspan\u003e Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1. Uda, A., et al. (2001). CD3 polymorphism in cynomolgus monkeys (Macaca fascicularis). Journal of Medical Primatology, 30(3), 141-147.\u003cbr\u003e2. Wang, Z., et al. (2004). Expression and characterization of recombinant soluble monkey CD3 molecules: mapping the FN18 polymorphic epitope. Molecular Immunology, 40(16), 1179-1188.\u003cbr\u003e3. Liu, Y.Y., et al. (2007). Polymorphisms of CD3epsilon in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins. Immunology and Cell Biology, 85(5), 357-362.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eCynomolgus macaque (Macaca fascicularis) CD3E protein is a key signaling subunit of the T cell receptor (TCR)-CD3 complex, encoded by the CD3E gene (Gene ID: 102133065) with UniProt accession Q95LI5. Together with CD3D, CD3G, and CD3Z, it forms the invariant signaling module of the TCR-CD3 complex, responsible for transducing antigen recognition signals into the T cell interior.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eExpression and Structural Features: The ectodomain of cynomolgus CD3E corresponds to the Gln22-Asp117 region. When the recombinant ectodomain fragment (Gln22-Asp117) is produced in the Expi293 expression system, its apparent molecular weight (43-48 kDa) is typically higher than the calculated value (36.9 kDa) due to glycosylation modifications.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":67396710760523,"sku":"UA016235-25μg","price":345.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67396710793291,"sku":"UA016235-100μg","price":680.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67396710826059,"sku":"UA016235-500μg","price":1895.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":67396710858827,"sku":"UA016235-1mg","price":2845.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/a16e32ad6581416595b5fcb1892238f2_ab46febd-b2f9-41c0-9324-f940bf8accd9.jpg?v=1793840474","url":"https:\/\/www.antbioinc.com\/products\/cd3-epsilon-fchis-tag-protein-cynomolgus-ua016235","provider":"AntBio","version":"1.0","type":"link"}