{"product_id":"biotinylated-integrin-alpha-vbeta-8itgavitgb8-hisavi-tagtag-free-protein-human-ua016116","title":"Biotinylated Integrin alpha V\u0026beta 8(ITGAV\u0026ITGB8) His,Avi Tag\u0026Tag Free Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIntegrin alpha V beta 8, ITGAV\u0026amp;ITGB8\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eNP_002201.1、NP_002205.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003eITGAV:Phe31-Val992with Acidic tail\u0026amp;His\u0026amp;Avi Tag at the C-Terminus; \u003c\/p\u003e\n\u003cp\u003eITGB8:Glu43-Arg684with Basic Tail at the C-Terminus ; \u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e90-100kDa\u0026amp;110-130kDa\u0026amp;130-180kDa(Reducing)\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eBiotin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAvi Tag, His Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized Powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003ca\u003e·\u003c\/a\u003e 12 months from date of receipt, lyophilized powder stored at -20 to-80℃. \u003c\/p\u003e\n\u003cp\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution. \u003c\/p\u003e\n\u003cp\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003eITGAV (integrin subunit alpha V) and ITGB8 (integrin subunit beta 8) non-covalently pair to form the αvβ8 heterodimer, the only integrin in which β8 exclusively associates with αv. It is minimally expressed in normal tissues but upregulated in solid tumors and fibrosis. Functionally, αvβ8 binds latent TGF-β complexes and mediates local TGF-β activation, driving an immunosuppressive tumor microenvironment and fibrosis; it also regulates microglial development and serves as a viral attachment receptor. Clinically, the αvβ8-blocking antibody CRB-601 has entered phase I\/II trials in solid tumors, and the oral αvβ8\/αvβ1 inhibitor PLN-101095 combined with immune checkpoint inhibition shows synergistic antitumor effects. ITGB8 is overexpressed in ovarian cancer and promotes invasion via PI3K-AKT-NF-κB, serving as a potential prognostic biomarker. These advances support αvβ8-targeted therapy and diagnostics. \u003cbr\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":48961092026443,"sku":"UA016116-25μg","price":345.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":48961092059211,"sku":"UA016116-100μg","price":680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/a5cfb1d0-aa1c-4fd5-b4cf-f842c6933982_458d14a0-add3-4b6e-bece-86eeec148c92.jpg?v=1790654409","url":"https:\/\/www.antbioinc.com\/products\/biotinylated-integrin-alpha-vbeta-8itgavitgb8-hisavi-tagtag-free-protein-human-ua016116","provider":"AntBio","version":"1.0","type":"link"}