{"product_id":"biotinylated-cd8-alphacd8a-hisavi-tag-protein-human-ua016229","title":"Biotinylated CD8 alpha\/CD8A His\u0026Avi Tag Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCD8, Leu2, MAL, p32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP01732-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eSer22-Asp182 with His\u0026amp;Avi Tag at the C-Terminus\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003e25-35kDa (Reducing)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞90% by SDS-PAGE\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eBiotin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAvi Tag, His Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cspan\u003e· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 3 months, -20 to -80℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· 1 week, 2 to 8℃ under sterile conditions after reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e· Please avoid repeated freeze-thaw cycles.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1. Andreata F, Moynihan K D, Fumagalli V, et al. CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus[J]. Science Translational Medicine, 2024, 16(729): eadi1572.\u003cbr\u003e2. Baybutt T R, Entezari A A, Caspi A, et al. CD8α structural domains enhance GUCY2C CAR-T cell efficacy[J]. Cancer Biology\u0026amp;Therapy, 2024, 25(1): 2398801.\u003cbr\u003e3. Jones H F, Aretz Z E H, Gejman R S, et al. CD8 co-receptor modulates the specificity profile of the 1G4 TCR against NY-ESO-1[J]. Molecular Therapy, 2026, 34(1): 479-493.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan\u003eCD8α (the CD8 alpha chain, encoded by CD8A) is the α chain of the CD8 co-receptor, a type I transmembrane glycoprotein of the immunoglobulin superfamily composed of an extracellular Ig-like V domain, hinge and transmembrane regions, and a short cytoplasmic tail. It assembles with CD8β into the CD8αβ heterodimer or as the CD8αα homodimer. As a co-receptor for the T-cell receptor (TCR), CD8α binds MHC class I molecules and recruits Lck, thereby increasing antigen-recognition sensitivity and lowering the activation threshold of cytotoxic T cells; its expression also modulates TCR specificity and avidity. Clinically, CD8α\/CD8 has become an attractive target: CD8 cis-targeted IL-2 selectively reactivates dysfunctional CD8⁺ T cells against chronic hepatitis B; CD8-targeted DARPin-AAV enables in vivo T-cell gene delivery and CAR engineering; CD8-targeted nanobody PET tracers such as SNA006 non-invasively monitor tumour CD8⁺ T-cell infiltration and immunotherapy response; and CD8α hinge\/transmembrane domains improve CAR-T affinity and antitumour efficacy.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":67241211527243,"sku":"UA016229-25μg","price":345.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":67241211560011,"sku":"UA016229-100μg","price":680.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":67241211592779,"sku":"UA016229-500μg","price":2030.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":67241211625547,"sku":"UA016229-1mg","price":3045.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/23854c2fdce540fd938dd4ef5b77b8f9_bdc89707-9b6d-4f0f-9ec2-25e6130da6a5.png?v=1792011704","url":"https:\/\/www.antbioinc.com\/products\/biotinylated-cd8-alphacd8a-hisavi-tag-protein-human-ua016229","provider":"AntBio","version":"1.0","type":"link"}