{"product_id":"biotinylated-cd20-flagavi-tag-full-length-protein-human-detergent-ua060040","title":"Biotinylated CD20 Flag\u0026Avi Tag Full Length Protein, Human (Detergent)","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMS4A1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP11836\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e1 mg\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003eMet1–Pro297 with a Flag\u0026amp;Avi Tag at the C-terminus.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e40 kDa (Reducing)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e＞85% by SDS-PAGE \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eBiotin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eFlag Tag, Avi Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e25 mM Hepes, pH7.5, 150 mM NaCl, 0.006%GDN\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e\u003cspan\u003eStable for 3 months upon stored at -80\u003c\/span\u003e\u003cspan\u003e℃\u003c\/span\u003e\u003cspan\u003e from the date of receipt. And avoid repeated freeze-thaws cycles.\u003c\/span\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReference\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e1. Rougé L, Chiang N, Steffek M, Kugel C, Croll TI, Tam C, Estevez A, Arthur CP, Koth CM, Ciferri C, Kraft E, Payandeh J, Nakamura G, Koerber JT, Rohou A. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab. Science. 2020 Mar 13;367(6483):1224-1230.\u003cbr\u003e2. Kung JE, Johnson MC, Tegunov D, Jao CC, Wu P, Oh A, Lin M, Daria JM, Koth CM, Arthur CP, Rohou A, Sudhamsu J. Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM. Nat Commun. 2025 Sep 30;16(1):8687.\u003cbr\u003e3. Kumar A, Planchais C, Fronzes R, Mouquet H, Reyes N. Binding mechanisms of therapeutic antibodies to human CD20. Science. 2020 Aug 14;369(6505):793-799.\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eCD20 is a B\u003c\/span\u003e\u003cspan\u003e-\u003c\/span\u003e\u003cspan\u003ecell\u003c\/span\u003e\u003cspan\u003e-\u003c\/span\u003e\u003cspan\u003especific membrane protein encoded by MS4A1 (chromosome 11q12), belonging to the MS4A family. It has four transmembrane helices and a key extracellular epitope (¹⁷⁰ANPSE¹⁷⁴), forming a tight homodimer that lacks a transmembrane pore, arguing against direct ion\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003echannel function. CD20 is expressed from pre\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003eB to mature B cells, lost on plasma cells, and highly overexpressed on malignant B cells in lymphomas, chronic lymphocytic leukaemia (CLL) and autoimmune diseases, establishing it as a validated therapeutic target.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAnti\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003eCD20 monoclonal antibodies fall into two types. Type I (rituximab, ofatumumab) bind two Fabs per dimer through homotypic Fab–Fab interactions, potently activating complement\u003c\/span\u003e\u003cspan\u003e-\u003c\/span\u003e\u003cspan\u003edependent cytotoxicity (CDC). Type II (obinutuzumab) bind with 1:2 stoichiometry, showing reduced CDC but enhanced direct killing. These antibodies have transformed treatment, though resistance and relapse persist. Recent cryo\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003eEM structures (2.6–3.3 Å) have revealed the molecular basis of these differential binding modes, providing a framework for rationally designing next\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003egeneration CD20\u003c\/span\u003e\u003cspan\u003e‑\u003c\/span\u003e\u003cspan\u003etargeted immunotherapies.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":43084195627083,"sku":"UA060040-25μg","price":1655.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43084195659851,"sku":"UA060040-100μg","price":3675.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/d957e4cdc7e448b0b5fe7f0d699aa121.png?v=1787950901","url":"https:\/\/www.antbioinc.com\/products\/biotinylated-cd20-flagavi-tag-full-length-protein-human-detergent-ua060040","provider":"AntBio","version":"1.0","type":"link"}