{"product_id":"biotinylated-b7-h3-4igb7-h3b-hisavi-tag-protein-human-ua016139","title":"Biotinylated B7-H3 (4Ig)\/B7-H3b His\u0026Avi Tag Protein, Human","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCD276 antigen,4Ig-B7-H3,B7 homolog 3 (B7-H3),B7H3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eQ5ZPR3-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAmino Acid Sequence\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e\u003cbr\u003eGly27-Thr461 with His\u0026amp;Avi Tag at the C-Terminus\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e \u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eExpression System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHEK293\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eMolecular Weight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e70-100kDa (Reducing)\u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u0026lt;1EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAvi Tag, His Tag\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, pH7.4, 5% trehalose \u003cbr\u003e\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReconstitution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp style=\"margin-bottom: 0px;\"\u003eReconstitute at 0.1-1 mg\/ml according to the size in ultrapure water after rapid centrifugation\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\n\u003cp\u003e· 12 months from date of receipt,lyophilized powder stored at -20 to -80℃.\u003c\/p\u003e\n\u003cp\u003e· 3 months, -20 to -80℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· 1 week, 2 to 8℃under sterile conditions after reconstitution.\u003c\/p\u003e\n\u003cp\u003e· Please avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003eB7-H3 (CD276) is an immune checkpoint molecule whose protein structure in humans primarily features tandemly repeated Ig-like V-C domains (VC domains) due to gene duplication, whereas mice contain only a single VC domain. This protein participates in regulating T-cell-mediated immune responses, with both isoform 1 and isoform 2 capable of modulating CD4+ T-cell reactions, among which isoform 2 enhances the induction of cytotoxic T cells and selectively stimulates IFN-γ production in the presence of TCR signaling. In tumors, B7-H3 exerts a protective effect by inhibiting natural killer (NK) cell-mediated lysis, and also serves as a detection marker for neuroblastoma. Furthermore, it plays a role in acute and chronic transplant rejection as well as in the regulation of lymphocytic activity at mucosal surfaces, and contributes to establishing a suitable immunological environment for the placenta and fetus during pregnancy. Its clinical significance lies in its potential as a therapeutic target for tumor immunotherapy and transplant rejection intervention, as well as its research value in pregnancy-related immune regulation.\u003cbr\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"UA BIOSCIENCE","offers":[{"title":"25μg","offer_id":43204936466507,"sku":"UA016139-25μg","price":430.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":43204936499275,"sku":"UA016139-100μg","price":850.0,"currency_code":"USD","in_stock":true},{"title":"500μg","offer_id":43204936532043,"sku":"UA016139-500μg","price":2240.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":43204936564811,"sku":"UA016139-1mg","price":3360.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/a28b953e-3e11-4bfe-9f53-d0e723c5e893_5174d848-13c8-4898-adc3-111d2efa39af.jpg?v=1789610556","url":"https:\/\/www.antbioinc.com\/products\/biotinylated-b7-h3-4igb7-h3b-hisavi-tag-protein-human-ua016139","provider":"AntBio","version":"1.0","type":"link"}