{"product_id":"alexa-fluor-647-mouse-anti-human-gpr183-ebi2-antibody-s-3016-s0b80252","title":"Alexa Fluor® 647 Mouse Anti-Human GPR183 (EBI2) Antibody (S-3016)","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMouse\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eGPR183 (EBI2)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eG-protein coupled receptor 183; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2; EBV-induced G-protein coupled receptor 2; hEBI2)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eLocation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCell membrane\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eP32249\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eClone Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eS-3016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMouse mAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIgG2a,k\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eFCM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eHu\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePositive Sample\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003ehuman PBMC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProtein A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e0.2 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAlexa Fluor® 647\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, 1% BSA, 0.09% sodium azide\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e12 months from date of receipt \/ reconstitution, 2 to 8 °C as supplied\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eDilution\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 60%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eapplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003edilution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003especies\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFCM\u003c\/td\u003e\n\u003ctd\u003e5μl per million cells in 100μl volume\u003c\/td\u003e\n\u003ctd\u003eHu\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan style=\"color:#000000\"\u003eGPR183 (also designated Epstein\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e–\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eBarr virus-induced gene 2, EBI2) is a seven-transmembrane G\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eα\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003ei\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e-coupled GPCR discovered through its strong up-regulation in Epstein\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e–\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eBarr virus\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e–\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003einfected Burkitt lymphoma cells; it is expressed on B cells, T cells, dendritic cells and other immune and non-immune cells, binds the oxysterol 7\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eα\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e,25-dihydroxycholesterol (7\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eα\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e,25-OHC) as its most potent endogenous ligand, and drives chemotaxis and positioning of B and T cells within secondary lymphoid organs by sensing oxysterol gradients generated by the enzymes CH25H and CYP7B1; downstream \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003esignalling\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e involves calcium \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003emobilisation\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e, ERK1\/2 and p38 MAPK activation, \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eβ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e-\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003earrestin\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e recruitment and SRE-mediated transcription, thereby orchestrating adaptive immune responses, while genetic or pharmacologic interference with the GPR183\/7\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eα\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e,25-OHC axis leads to impaired antibody production, defective plasma-cell \u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003elocalisation\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e and altered trafficking of innate lymphoid cells, and has implicated the receptor in autoimmune, inflammatory and viral diseases, making GPR183 and its ligand attractive therapeutic targets.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"25T","offer_id":43095289430091,"sku":"S0B80252-25T","price":275.0,"currency_code":"USD","in_stock":true},{"title":"100T","offer_id":43095289462859,"sku":"S0B80252-100T","price":470.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/36c55f09a7f04efc90db281763d9a2b6.jpg?v=1788213736","url":"https:\/\/www.antbioinc.com\/products\/alexa-fluor-647-mouse-anti-human-gpr183-ebi2-antibody-s-3016-s0b80252","provider":"AntBio","version":"1.0","type":"link"}