{"product_id":"alexa-fluor-488-armenian-hamster-anti-mouse-cd183-antibody-cxcr3-173-s0b80585","title":"Alexa Fluor® 488 Armenian hamster Anti-Mouse CD183 Antibody (CXCR3-173)","description":"\u003ch4\u003eProduct Specification\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 100%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eHost\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eArmenian hamster\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntigen\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCD183\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eSynonyms\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eC-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor (IP-10 receptor); Cmkar3; Cxcr3\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eLocation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCell membrane\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAccession\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eO88410\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eClone Number\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eCXCR3-173\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eAntibody Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eRecombinant mAb\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eIsotype\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eFCM\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eReactivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eMs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePositive Sample\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eFresh C57BL\/6 mouse splenocytes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePurification\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eProtein G\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e0.5 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eConjugation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eAlexa Fluor® 488\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003ePhysical Appearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003eLiquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStorage Buffer\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003ePBS, 1% BSA, 0.09% sodium azide\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 22%;\"\u003e\u003cstrong\u003eStability \u0026amp; Storage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 78%;\"\u003e\u003cp\u003e12 months from date of receipt \/ reconstitution, 2 to 8 °C as supplied\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eDilution\u003c\/h4\u003e\u003cdiv class=\"responsive-table product-detail-table details-table\"\u003e\n\u003cbr\u003e\u003ctable style=\"width: 60%; height: auto;\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eapplication\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003edilution\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003especies\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFCM\u003c\/td\u003e\n\u003ctd\u003e1μg per million cells in 100μl volume\u003c\/td\u003e\n\u003ctd\u003eMs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\u003c\/div\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cdiv\u003e\u003cp\u003e\u003cspan style=\"color:#000000\"\u003eCD183, also known as CXCR3, is a 40-kDa, seven-transmembrane G-protein-coupled receptor encoded on chromosome Xq13 that selectively binds the IFN-\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eγ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e-inducible chemokines CXCL9, CXCL10 and CXCL11; upon ligation it triggers Gi-mediated signaling cascades (MAPK, PI3K\/AKT, PLC\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eβ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e3\/\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eμ\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e-calpain, cAMP\/PKA and p38MAPK) that induce rapid integrin activation, cytoskeletal rearrangement and chemotactic migration of activated\/memory CD4\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e⁺\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e and CD8\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e⁺\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e T cells, NK cells and endothelial cells, thereby orchestrating Th1-oriented inflammatory responses, anti-viral immunity and angiostasis; the receptor exists in three alternatively spliced isoforms (CXCR3-A, -B and -alt) that differ in their C-termini and third intracellular loop, enabling ligand-specific functional bias\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e—\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eCXCR3-A promotes proliferation, survival and invasion, whereas CXCR3-B mediates growth inhibition, apoptosis and vascular suppression\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003e—\u003c\/span\u003e\u003cspan style=\"color:#000000\"\u003eand is prominently expressed in inflamed tissues and various cancers, making it a key therapeutic target for autoimmune, neoplastic and infectious diseases.\u003c\/span\u003e\u003c\/p\u003e\u003c\/div\u003e","brand":"Starter","offers":[{"title":"25 μg","offer_id":42898134728779,"sku":"S0B80585-25 μg","price":100.0,"currency_code":"USD","in_stock":true},{"title":"100 μg","offer_id":42898134761547,"sku":"S0B80585-100 μg","price":235.0,"currency_code":"USD","in_stock":true},{"title":"200 μg","offer_id":42898134794315,"sku":"S0B80585-200 μg","price":435.0,"currency_code":"USD","in_stock":true},{"title":"500 μg","offer_id":42898134827083,"sku":"S0B80585-500 μg","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/8375\/1499\/files\/AntBioImage_1111f3f5-dadb-4d9c-b944-7b8027ab2253.png?v=1784120579","url":"https:\/\/www.antbioinc.com\/products\/alexa-fluor-488-armenian-hamster-anti-mouse-cd183-antibody-cxcr3-173-s0b80585","provider":"AntBio","version":"1.0","type":"link"}